Lake County was formed in 1861 from parts of Napa and Mendocino counties,[8] but the area had European-American settlers from at least the 1840s. Lake County has long been known as a farming community.

The 1911 California Blue Book lists the major crops as Bartlett pears and beans. Other crops include grain, alfalfa, hay, prunes, peaches, apples, grapes, and walnuts. Stockraising included goats, hogs, turkeys, and dairying.

Some vineyards were planted in the 1870s by European Americans but the first in the state were established in the 18th century by Spanish missionaries. By the early 20th century, the area was earning a reputation for producing some of the world’s greatest wines. However, in 1920, national Prohibition essentially ended Lake County’s wine production. With authorized cultivation limited to sacramental purposes, most of the vineyards were ripped out and replanted with walnut and pear orchards.